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FLASH GENE
Symbol ADH1C contributors: mct - updated : 15-09-2010
HGNC name alcohol dehydrogenase 1C (class I), gamma polypeptide
HGNC id 251
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated MetalloP
HOMOLOGY
Homologene
FAMILY
  • zinc-containing alcohol dehydrogenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • alcohol dehydrogenase (class I), gamma polypeptide, zinc dependent, playing a major role in ethanol catabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism alcohol , other
    signaling
    a component
  • dimer of identical or nonidentical chains of three types; alpha, beta and gamma
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • NAD+
  • binds 2 zinc ions per subunit
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to alcoholism in Chinese people (allele 1)
  • to Parkinson disease
  • Variant & Polymorphism other
  • increased risk of alcohol dependence in American Indian population
  • increasing the risk of Parkinson disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS