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FLASH GENE
Symbol ADH1A contributors: mct/ - updated : 14-06-2006
HGNC name alcohol dehydrogenase 1A (class I), alpha polypeptide
HGNC id 249
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated MetalloP
mono polymer homomer , heteromer , dimer
HOMOLOGY
Homologene
FAMILY
  • zinc-containing alcohol dehydrogenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text detected in the inner cell layers (Vaglenova 2003)
    basic FUNCTION
  • alcohol dehydrogenase (class I), alpha polypeptide, zinc dependent, metabolizing a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products
  • acting as retinol dehydrogenase/retinal reductase, also sites of active retinoid metabolism in the gut, essential for mucosa function and vitamin A absorption (Vaglenova 2003)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    ethanol
    a component
  • homo- and heterodimers of alpha, beta, and gamma subunits
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • SNIP1
  • cell & other
    REGULATION
    Other regulated by GATA2 and HNF-3beta
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increased expression of ADH1A and ADH4 in non-alcoholic steatohepatitis livers (baker 2010)
    Susceptibility to alcohol dependence
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS