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FLASH GENE
Symbol ACR contributors: mct - updated : 09-02-2008
HGNC name acrosin
HGNC id 126
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
text acrosome
basic FUNCTION
  • serine proteinase with trypsin-like specificity
  • major proteinase present in the acrosome of mature spermatozoa
  • function both in the limited proteolysis of the zona pellucida, and in the maintenance of binding of acrosome-reacted sperm to the zona
  • having functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    text lysis of the zona pellucida
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS