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FLASH GENE
Symbol CD48 contributors: mct/pgu - updated : 16-07-2010
HGNC name CD48 molecule
HGNC id 1683
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Ig-like C2-type (immunoglobulin-like) domain
  • a Ig-like V-type (immunoglobulin-like) domain
  • conjugated GlycoP , LipoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • SLAM family
  • CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text attached to the membrane by a GPI-anchor
    basic FUNCTION
  • may be involved in regulating T-cell activation
  • ligand for CD2
  • might facilitate interaction between activated lymphocytes
  • cooperating with CD2 in the buildup of the early TCR signalosome and shuttling the transmembrane adapter membrane LAT
  • induces numerous effects in B and T lymphocytes, natural killer cells, mast cells, and eosinophils
  • SLAMF1, CD48, CD84, CD244, LY9, SLAMF6, SLAMF7 play an essential and non-redundant role in the control of humoral immune responses
  • plays a vital role as an environmental sensor for regulating hematopoietic cells and progenitor cell numbers and inhibiting tumor development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to 2B4
  • binds CD2 and other molecules
  • cell & other
    REGULATION
    Other its expression is regulated by viral and bacterial products and immune-associated proteins
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility may have a role in the susceptibility to EBV infection in patients with mutation in XPLD disease gene
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS