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FLASH GENE
Symbol ATF2 contributors: mct/pgu - updated : 12-07-2017
HGNC name activating transcription factor 2
HGNC id 784
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic leucine zipper (bZIP) protein
  • zinc finger motif
  • proline-rich motif
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Atf2
    intraspecies homolog to ATF7
    Homologene
    FAMILY
  • bZIP family
  • ATF subfamily
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • regulates transcription in response to stress and growth factor stimuli
  • mediating the E1A responsiveness
  • acting as a tumor supressor gene in lung cancer
  • playing an important role in the mediation of cellular stress responses, development and transformation
  • having a suppressor activity in skin tumor formation
  • activates the transcription of apoptosis-related genes
  • may be a key regulator of the insulin promoter possibly stimulating activity in response to extracellular signals
  • transcription factor important for normal cellular development and survival
  • in cooperation with mutated oncogenes or tumor suppressor genes, can also elicit tumor suppressor function
  • may be a key regulator of the insulin promoter possibly stimulating activity in response to extracellular signals
  • importance of transcriptionally active ATF2 in melanoma development through fine-tuning of MITF expression (
  • ATF2 was required for other endothelial cell outputs, such as cell migration and tubulogenesis
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • cAMP response element of many viral and cellular proteins
  • CNTN2 (for activation HTLV-1 promoter)
  • DDIT3
  • interacting with NCOA6 by its N-terminal transactivation domain to induce target gene transcription during granulocytic differentiation
  • binding CRE2 site of INS
  • binds directly to both MAPKAP1 and MAPK14
  • regulating ATM activation by control of KAT5 stability and activity
  • interacts with beta-cell-enriched transcription factors, MAFA, PDX1, and NEUROD1, and activates insulin gene transcription
  • ATF2 likely functionally required for VEGFA-stimulated endothelial VCAM1 gene expression
  • cell & other
    REGULATION
    activated by virus
    mitogen activated protein kinase (MAPK) pathways
    stress and growth factors that activate ATF2 and ATF7 mainly via sequential phosphorylation of two conserved threonine residues in their activation domain
    inhibited by polyamines (negatively regulate ATF2 expression posttranscriptionally and polyamine depletion stabilizes ATF2 mRNA by enhancing the interaction of the 3prime-untranslated region (UTR) of ATF2 with cytoplasmic ELAVL1)
    Other phosphorylated by MAPK14/Jun NH2-terminal protein kinase
    phosphorylated at Serine 121 by protein kinase C (controls c-Jun-mediated activation of transcription)
    the MEKK/MKK7/JNK2 module is responsible for ATF2 phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in skin carcinogenesis
    tumoral     --over  
    associated with prolonged survival in mammary carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS