Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PDE6B contributors: mct - updated : 15-06-2011
HGNC name phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant)
HGNC id 8786
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N terminal cGMP binding domains
  • a C terminal catalytic domain
  • conjugated LipoP
    mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to murine Rd
    ortholog to murine Pde6b
    ortholog to Cani familiari PDBS
    Homologene
    FAMILY cyclic nucleotide phosphodiesterase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text
  • membrane-associated
  • basic FUNCTION
  • participating in processes of transmission and amplification of the visual signal
  • being necessary for the formation of a functional phosphodiesterase holoenzyme
  • central enzyme in the visual transduction cascade
  • key effector enzyme of the phototransduction cascade in rods and cones
  • catalytic PDE6A and PDE6B subunits are enzymatically equivalent
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
  • oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain
  • prenylation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ARRP2 , CSNB3
    related resource PDE6BMutations
    Retinal Information Network
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS