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FLASH GENE
Symbol KRT6B contributors: npt/mct - updated : 08-06-2018
HGNC name keratin 6B
HGNC id 6444
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved central rod domain, made of four helical domains (1A,1B,2A,2B) interrupted by non alpha helical linkers (L1,2,3)
  • the homology domains H1 and H2, variable region (V1,V2), end sequences (E1,E2)
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Krt2-6b
    ortholog to C.elegans F58E10.3
    Homologene
    FAMILY
  • intermediate filament family
  • type II keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text expressed with family members KRT16 and/or KRT17
    basic FUNCTION
  • required for filament assembly
  • CELLULAR PROCESS cell life, proliferation/growth
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text
  • cell shape and cell size control
  • ectoderm development
  • PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with KRT17 and/or KRT16
  • heterodimer of a type I (acidic) and a type II (neutral to basic) keratin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PC212
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS