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FLASH GENE
Symbol YWHAH contributors: mct/npt - updated : 27-01-2021
HGNC name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
HGNC id 12853
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • 14-3-3 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • component of the cardiac Na(+) channel acting as a cofactor for the regulation of the cardiac Na(+) current
  • inhibitor of apoptosis through inhibiting the activation of MAPK14
  • functioning as a positive regulator in the glucocorticoid signal pathway by blocking the degradation of glucocorticoid receptor (GR) and inducing an elevation of GR, thus enhancing the transcriptional activity of GR
  • inhibitor of ZBTB17
  • chaperone-like protein present abundantly in neurons, that could bind to parkin and negatively regulate its ubiquitin ligase activity
  • regulator that functionally links parkin and SNCA
  • may be playing a regulatory role in chondrogenic differentiation
  • key regulator in the growth impairment of children with joint inflammatory disease
  • may be likely required for mitotic progression and may be considered as a novel anti-cancer strategy in combination with microtubule inhibitors
  • could be a critical factor in the survival of outer hair cells
  • role of YWHAH overexpression and inefficient oxidative phosphorylation in oncocytoma mitochondrial biogenesis
  • YWHAH chaperone protein promotes antiviral innate immunity via facilitating IFIH1 oligomerization and intracellular redistribution
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • HDAC7 directly binds to beta-catenin and forms a complex with YWHAE, YWHAZ, and YWHAH proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • p38 MAP kinase
  • interaction with YWHAB, YWHAE, ATXN1, YWHAZ mediated by AKT1 to modulate the neurotoxicity of SCA1
  • interacting with SCN5A cytoplasmic I interdomain
  • GREM1 interacted with YWHAH (YWHAH binding site for gremlin 1 was located between AAs 61-80 and gremlin 1 binding site for YWHAH was found to be located between AAs 1 to 67)
  • directly regulate CAMK1 when the enzyme is phosphorylated by protein kinase A on either Ser74 or Ser475
  • YWHAH is an essential accessory protein for IFIH1-dependent type I IFN induction
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in synovial fluid from patients with joint inflammation
    tumoral   deletion    
    with DEPDC5, C22ORF24, in glioblastomas
    constitutional     --over  
    significantly higher in patients in patients rheumatoid arthritis with radiographically assessed joint damage and in those who had radiographic progressionwith radiographically assessed joint damage and in those who had radiographic progression
    Susceptibility to rs2246704 was associated with BP (bipolar disorder)
    Variant & Polymorphism SNP rs2246704 was associated with bipolar disorder
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • differential expression of YWHAH, YWHAQ throughout brain regions of rats with insulin resistance
  • 14-3-3eta-deficient mice displayed auditory impairment accompanied by cochlear hair cells' degeneration