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FLASH GENE
Symbol SOD3 contributors: mct - updated : 24-08-2017
HGNC name superoxide dismutase 3, extracellular
HGNC id 11181
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an heparin-binding domain (HBD), important to restore vascular dysfunction produced by endotoxin
  • C-terminal region is involved in formation of the quaternary structure
    • mono polymer homomer , tetramer , octamer
    HOMOLOGY
    Homologene
    FAMILY superoxide dismutase (SOD) protein family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text a secreted protein found in the extracellular matrix of tissues (Takada 2009)
    basic FUNCTION
  • antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen
  • invoved in catabolic pathway of activated oxygen species, and free radical detoxification
  • may be protecting the brain, lungs, and other tissues from oxidative stress
  • tetrameric metalloenzyme responsible for the removal of superoxide anions from the extracellular space
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen
  • SOD3 octamer with high affinity may represent a way to influence the local concentration of EC-SOD to protect tissues specifically sensitive to oxidative damag
    • INTERACTION
    DNA
    RNA
    small molecule
    protein with fibulin 5 (interaction may represent a novel mechanism for controlling vascular redox state in the extracellular space in various cardiovascular diseases such as atherosclerosis and hypertension in which oxidative stress is increased)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in aortic dissection
    Susceptibility
  • to ischaemic heart disease
  • to insulin resistance and the susceptibility to type 2 diabetes
    • Variant & Polymorphism other predisposing carriers to ischaemic heart disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS