protein
| activating transcription factor-1, ATF1 |
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YY1 transcription factor, YY1 |
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Abelson murine leukemia virus, v-Abl |
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serum response factor, SRF |
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homeoprotein LFB3 |
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GLI family zinc finger 2, GLI2 |
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Tat interactive protein 60 kDa, TIP60 |
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Histone binding protein RbAp48 |
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CCAAT/enhancer binding protein (C/EBP) beta, CEBPB |
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MECT1-MAML2 complex |
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PSEN1 |
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bound CRTC1 (to regulate CARTPT and KISS1 gene expression through a direct mechanism) |
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is a critical regulator of human GRPR expression in gastrointestinal cancer and might be activated through different upstream intracellular pathways |
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binding to HDAC8 (inactivating CREB1 activation and decreasing CREB1 mediated gene transcription) |
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SRY (sex determining region Y)-box 9, SOX9 |
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binding partner for LYL1 but not for TAL1 |
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interaction with CCDC6 reduces CREB1 binding to AREG promoter |
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CREB1, SP1, and TFAP4 play roles in modulating PPP2R2B expression |
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interacting with TOX3 |
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SIK2 plays critical roles in neuronal survival, is modulated by CaMKI/IV, and regulates CREB1 via CRTC1 |
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protein target of PTEN phosphatase and PTEN deficiency leads to CREB1 phosphorylation independent of the PI3K/AKT pathway |
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CREB1 gene silencing decreased IL13-induced transcription of eotaxin-3 (CCL26) |
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new role for TIRAP as a key upstream regulator of CREB1 and as a contributor to the expression of both pro- and anti-inflammatory genes |
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RCAN1 acting as an important regulatory component in the control of CREB1 signaling |
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BDNF uses CREB1 and EGR3 to regulate NMDA receptor levels in cortical neurons |
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complex interplay between CREB1 and SIRT1: CREB1 directly regulates the transcription of the sirtuin in neuronal cells by binding to SIRT1 chromatin and, in turn, is recruited by CREB1 to DNA |
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NR4A2 is a downstream target of CREB1 and it is responsible for the NMDA-mediated increase in BDNF, which is necessary for the NMDA-mediated prosurvival effect on neurons |
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SOX4 transcription factor is a gene that cooperates with CREB1 in myeloid leukemogenesis |
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CREB1 has been postulated to regulate TRH expression |
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overactivation of CAPN1 caused by calcium overload proteolyses CREB1, resulting in a reduction of SLC2A3 expression and consequently impairing glucose uptake and metabolism in AD brain |
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CREB1 mediates the PRKAA-stimulated degradation of GRIP1 through protein-protein interaction and stimulation of proteasomal degradation of ubiquitinated GRIP1 |
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is necessary for the specific maintenance of the GRIA1 subunit and for its trafficking within the post-synaptic densities (PSD) during the occurrence of learning |
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CREB1 regulates TIGAR expression via a CRE-binding site at the TIGAR promoter |
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IGF1 regulates MSTN expression via CREB1 transcription factor during muscle cell differentiation |
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negative regulation of CREB1 activity by endogenous CAMK2D-dependent CREB1-Ser(142) phosphorylation, suggesting a potential mechanism for CAMK2D/CREB1 signaling in modulating proliferation and migration in vascular smooth muscle cells |
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KDELR1, KDELR2 activates CREB1 and other transcription factors that upregulate transport-related genes |
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is positioned to interact with the MEF2C pathway known to be important in developmental epilepsies and the CREB1 pathway implicated in epilepsy pathogenesis |
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CREB1 is a negative regulator of the TNFAIP1 gene |
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depletion of CREB1 decreased the expression of ERN1 and EIF2AK3, two critical UPR signaling molecules, and CREB1 binds to the promoter region of these genes and regulates their expression |
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GSK3A is regulated by CREB1 in lung cancer and is required for the cell viability |
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SMIM20 acts through GPR173 to activate the cAMP/protein kinase A pathway through CREB1, for a stimulatory effect on reproductive function |
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SMIM20 acts through its receptor, G protein-coupled receptor 173 (GPR173), to activate the cAMP/PKA pathway leading to the phosphorylation of CREB1 |
| transgenic mice expressing a dominant-negative form of the CREB1 develop dilated cardiomyopathy associated with hepatic congestion and peripheral edema, intracardiac thrombi, and premature mortality | |
CREB null mice are smaller, display a strong reduction in the corpus callosum and the anterior commissures in brain and die immediately after birth from respiratory distress |
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mice with a disruption of CREB1exhibit fasting hypoglycaemia and reduced expression of gluconeogenic enzymes |
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disrupted Creb1 and Crem in brain of developing and adult mice using the Cre/loxP system leads to progressive neurodegeneration in the hippocampus and in the dorsolateral striatum |
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mice harboring a null mutation in the Creb gene, sensory neurons exhibit excess apoptosis and degeneration, and display impaired axonal growth and projections |
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mice deficient in CREB activity have a fatty liver phenotype and display elevated expression of the nuclear hormone receptor PPAR-gamma (ID: 14614508) |
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mice expressing a dominant-negative CREB transgene exhibit a dystrophic phenotype along with reduced MEF2 activity |