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FLASH GENE
Symbol LRIG3 contributors: mct - updated : 08-01-2020
HGNC name leucine rich repeats and immunoglobulin like domains 3
HGNC id 30991
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY leucine-rich repeats and immunoglobulin-like domains (LRIG) protein family
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
basic FUNCTION
  • LRIG1 and LRIG3 overlap prominently in the developing vestibular apparatus and simultaneous removal of both genes disrupts inner ear morphogenesis
  • functions as a tumor suppressor by attenuating EGFR signaling pathway
  • may influence heart function and plasma lipid levels in mice and humans
  • have a function similar to that of LRIG1: tumor suppressor in human cancers
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LMO7 and LIMCH1 were identified as interaction partners to LRIG3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    might inhibit the viability, adhesion, invasion and migration and promote the apoptosis of Prostate cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    restoration of LRIG3 may offer therapeutic potential against malignant gliomas
    ANIMAL & CELL MODELS
  • Lrig3-deficient mice were smaller than the wild-type mice but otherwise appeared grossly normal