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FLASH GENE
Symbol TMEM63B contributors: mct - updated : 22-11-2019
HGNC name transmembrane protein 63B
HGNC id 17735
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION     plasma membrane
text
  • TMEM63B localizes to the plasma membrane and is associated with F-actin
  • basic FUNCTION
  • TMEM63A, TMEM63B, TMEM63C are required to constitute a hyperosmolarity activated ion channel, and may serve as an osmolarity sensitive ion channel for the osmoreception
  • TMEM63A, TMEM63B and TMEM63C might work in concert to constitute a hyperosmolarity activated ion channel
  • role in the cancer in which it is frequently overexpressed
  • promotes [Ca2+]i influx across the plasma membrane in response to extracellular [Ca2+] and hyperosmolarity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE95
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential role(s) of TMEM63B as a cancer biomarker
  • Therapy target
    ANIMAL & CELL MODELS