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FLASH GENE
Symbol PWWP2A contributors: mct - updated : 04-06-2019
HGNC name PWWP domain containing 2A
HGNC id 29406
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • PWWP domain exhibiting direct DNA binding
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • vertebrate-specific protein that binds very tightly to chromatin through a concerted multivalent binding mode (pMID: 28645917)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PWWP2A is a novel H2AFZ-nucleosome binder
  • PWWP2A is a novel H2AFZ-specific multivalent chromatin binder providing a surprising link between H2AFZ, chromosome segregation, and organ development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS