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FLASH GENE
Symbol MLST8 contributors: mct - updated : 09-01-2019
HGNC name MTOR associated protein, LST8 homolog
HGNC id 24825
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • MLST8 plays distinct roles in normal and cancer cells, depending upon its expression level
  • is an indispensable protein subunit of mammalian target of rapamycin (MTOR) signaling pathway that interacts with the kinase domain of mTOR protein, thereby stabilizing its active site
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MLST8 bridges between CAD and MTOR, and plays a role in the signaling mechanism where CAD is regulated in the MTOR pathway through the association with MLST8
  • MLST8 upregulation may contribute to tumor progression by constitutively activating both the MTOR and CRTC2 pathways
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in several human colon and prostate cancer cell lines and tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    targeting MLST8 protein would be a therapeutic approach against tumor progression in colon cancers
    cancerreproductiveprostate
    targeting MLST8 protein would be a therapeutic approach against tumor progression in prostate cancers
    ANIMAL & CELL MODELS