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FLASH GENE
Symbol WDR66 contributors: mct - updated : 17-10-2018
HGNC name WD repeat domain 66
HGNC id 28506
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine WD40-repeat domains circularly arranged around the central-pair complex of microtubules (9 + 2 structure)
  • one calcium-binding EF-hand domain is present in the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • localizes along the spermatozoon flagellum
  • basic FUNCTION
  • play an important role in esophageal squamous cell carcinoma growth and invasion as a positive modulator of epithelial-mesenchymal transition
  • plays a structural role during biogenesis of the spermatozoon flagellum in vertebrates
  • might be required for the extension of the mitochondrial sheath (MS) along the midpiece of the spermatozoon flagellum
  • is associated with sperm flagellar development and human male infertility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MIMAF5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation     loss of function
    cause sperm flagellar defects and human male infertility
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    might be a novel drug target for the treatment of esophageal squamous carcinoma
    ANIMAL & CELL MODELS