Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TRABD2B contributors: mct - updated : 30-10-2017
HGNC name TraB domain containing 2B
HGNC id 44200
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure two pairs of potential disulfide bonds that reside outside the beta-sheet catalytic core but likely assist the folding of the TIKI domain
conjugated MetalloP
HOMOLOGY
interspecies ortholog to TRABD2A
Homologene
FAMILY Tiki family
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • TRABD2A, TRABD2B exhibit specific expression during embryogenesis
  • mis-regulation of TRABD2A, TRABD2B in human cancer and diseases
  • TRABD2A, TRABD2B, are Wnt inhibitors that act by cleaving the Wnt amino-terminal region to inactivate specific Wnt ligands
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRABD2A, TRABD2B result in a WNT3A modification that minimizes Wnt3a activity but not secretion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    of TRABD2A, TRABD2B in osteosarcoma may participate in the progression of osteosarcoma and restoring its expression was able to impair the growth of osteosarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS