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FLASH GENE
Symbol MZB1 contributors: mct - updated : 15-03-2016
HGNC name marginal zone B and B1 cell specific protein
HGNC id 30125
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a thioredoxin-like active site motif (CXXC), which is the signature of oxidoreductases
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adhesion , immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • helps to diversify peripheral B cell functions by regulating Ca(2+) stores, antibody secretion, and integrin activation
  • is important for B cell function as a key regulator of antibody secretion, calcium homeostasis and adhesion
  • due to its biological function, MZB1 may play a central role in B cell neoplasms
  • B-cell-specific and endoplasmic reticulum (ER)-localized protein implicated in antibody secretion and integrin-mediated cell adhesion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MZB1 associates directly with the substrate-specific chaperone HSP90B1 in an ATP-sensitive manner and is required for the interaction of HSP90B1 with immunoglobulin heavy chain upon ER stress
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS