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FLASH GENE
Symbol SRGAP2B contributors: mct - updated : 22-02-2016
HGNC name SLIT-ROBO Rho GTPase activating protein 2B
HGNC id 35237
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a truncated F-BAR domain that lacks the last C-terminal 49 AA
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • inhibition of SRGAP2 function by SRGAP2B, SRGAP2C has contributed to the evolution of the human neocortex and plays an important role during human brain development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • both SRGAP2C, SRGAP2B can interact with ancestral SRGAP2A and inhibit its function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS