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FLASH GENE
Symbol WDR81 contributors: mct - updated : 16-12-2017
HGNC name WD repeat domain 81
HGNC id 26600
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal BEACH (Beige and Chediak-Higashi)domain
  • a major facilitator superfamily (MFS) domain
  • six WD repeats at the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text localized in mitochondria of Purkinje cell neurons
    basic FUNCTION
  • plays an essential role in Purkinje cells
  • WDR91 and WDR81 interact with BECN1 and inhibit PI3K complex activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WDR81 is a BEACH-domain containing protein that is also required for the degradation of EGF-stimulated epidermal growth factor receptor (EGFR) and functions in a complex with the WDR91 protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CHQL2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS