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FLASH GENE
Symbol PYCR2 contributors: mct - updated : 12-05-2015
HGNC name pyrroline-5-carboxylate reductase family, member 2
HGNC id 30262
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to zebrafish Picr1b
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
text
  • localized to mitochondria
    • basic FUNCTION
  • PYCR1 and PYCR2, which are localized in the mitochondria, are primarily involved in conversion of glutamate to proline
  • enzyme in the proline biosynthesis pathway
  • unique and indispensable role for PYCR2 in the CNS during development
  • PYCR1 and PYCR2 could play overlapping, yet non-redundant roles in mitochondrial physiology
  • is essential in maintaining mitochondrial membrane potential
  • is involved in the cell response to oxidative stress
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCHM
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS