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FLASH GENE
Symbol PEAK1 contributors: mct - updated : 21-08-2014
HGNC name pseudopodium-enriched atypical kinase 1
HGNC id 29431
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton
basic FUNCTION
  • tyrosine kinase that associates with the actin cytoskeleton and focal adhesion (FA) in migrating cells
  • plays an instrumental role in regulating the formation, maturation, and disassembly of FAs, which are pivotal for cell migration
  • with LYN is involved in a basal breast cancer signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a novel SFK-dependent focal adhesion (FA) regulator
  • PEAK1 and SRC work cooperatively to promote cell migration and invasion which has important implications for cancer metastasis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    n a subset of basal, HER2-positive, and luminal breast cancers
    tumoral     --over  
    in human pancreatic and colon cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a novel biomarker, and critical signaling hub inpancreatic ductal adenocarcinoma (PDAC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    disrupting PEAK1-SRC activities could be a fruitful avenue for therapeutic cancer treatment
    cancerdigestivepancreas
    new therapeutic target in pancreatic ductal adenocarcinoma (PDAC)
    ANIMAL & CELL MODELS