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FLASH GENE
Symbol MAGOHB contributors: mct - updated : 28-04-2014
HGNC name mago-nashi homolog B (Drosophila)
HGNC id 25504
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • MAGOH and MAGOHB contribute to exon junction complex composition and nonsense-mediated decay
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of STAU2 with the Y14-MAGOHB heterodimer seems to represent a highly conserved complex as the same proteins are involved in the STAU2-mediated localization of Oskar mRNA in Drosophila oocytes
  • in the presence of KMT2B, neither transcription elongation nor RNA polymerase II binding is required to maintain H3K4 trimethylation at the MAGOHB promoter and protect it from DNA methylation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS