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FLASH GENE
Symbol SIMC1 contributors: mct - updated : 11-04-2014
HGNC name SUMO-interacting motifs containing 1
HGNC id 24779
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region interacts with CTBP1
  • C-terminal sequence, which harbors the CAPN3 inhibitory or regulatory activity
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text primarily distributed diffusely in the cytoplasm
    basic FUNCTION
  • can shift its major function from CAPN3 suppression to CAPN3-substrate recruitment, depending on the cellular context
  • novel suppressor and scaffold for CAPN3, scaffolds CAPN3 to direct and regulate its substrate-proteolyzing activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a CAPN3-binding protein and suppresses the protease activity of CAPN3
  • also interacts with CTBP1 (C-terminal binding protein 1), a transcriptional co-regulator
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS