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FLASH GENE
Symbol PIK3R5 contributors: mct - updated : 10-02-2014
HGNC name phosphoinositide-3-kinase, regulatory subunit 5
HGNC id 30035
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to PIK3R6
Homologene
FAMILY
CATEGORY adaptor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
basic FUNCTION
  • required for G protein-mediated activation of PIK3CG in living cells
  • its overexpression ctivates PI3Kgamma signaling in T cells and contributes to cell survival (
  • differential functions of the two PIK3CG regulatory subunits PIK3R5, and PIK3R6 in the process of oncogenesis
  • may play a role in the development of the cerebellum and vermis
  • non-catalytic subunit assumed to be redundant adaptors for GNB1/GNGT1 enabling G-protein-coupled receptor-mediated regulation of PI3Kgamma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • regulatory subunit of phosphatidylinositol-3-kinase-gamma (PI3Kgamma)
  • PIK3CG has two potential regulatory subunits PIK3R5, PIK3R6
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • like PIK3R5, PIK3R6 binds to both PIK3CG and Gbetagamma and mediates activation of PIK3CG downstream of G protein-coupled receptors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS