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FLASH GENE
Symbol NAA60 contributors: mct - updated : 17-04-2013
HGNC name N(alpha)-acetyltransferase 60, NatF catalytic subunit
HGNC id 25875
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
text
  • localized in the Golgi apparatus
  • basic FUNCTION
  • essential regulator of normal chromosome segregation
  • catalyze the acetylation of free histones
  • displays a substrate preference for lysine AAs of free histone H4, including H4K79 and H4K91, that reside in the globular domain of H4
  • important player in the organization and function of the genome and may contribute to the diversity and complexity of higher eukaryotic organisms
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    impaired nucleosome assembly, inhibited cell proliferation, sensitized cells to DNA damage, and induced cell apoptosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS