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FLASH GENE
Symbol SETD3 contributors: mct - updated : 31-10-2012
HGNC name SET domain containing 3
HGNC id 20493
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SET (Su(var)3–9 domain found in histone methyltransferases and other lysine methyltransferases
  • Enhancer-of-zeste and Trithorax
  • Rubis-subs-bind domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • novel histone H3K4 and H3K36 methyltransferase with transcriptional activation activity
  • plays an important role in the transcriptional regulation of muscle cell differentiation, by regulating muscle-specific factors, most notably myogenin, through interaction with MYOD1
  • involved in a translocation to the immunoglobulin lambda light chain locus in one of the non-homologous end-joining/p53-deficient peripheral B cell lymphomas
  • exhibits histone methyltransferases activity on nucleosomal histone 3 in a SET-domain dependent manner
  • may play an important role in carcinogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with MYOD1 and is recruited to myogenin gene promoter
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS