Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ANXA5 contributors: mct - updated : 02-04-2007
HGNC name annexin A5
HGNC id 543
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a relatively short N terminus and a C terminal "core" region
  • four repeats homolog to the endonexin fold
  • mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Anxa5
    homolog to C.elegans Zc155?1
    Homologene
    FAMILY
  • annexin family and lipocortin family
  • chordate annexin family
  • CATEGORY regulatory , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • implicated in membrane-related events along exocytotic and endocytotic pathway
  • phospholipase A2 and protein kinase C inhibitory protein with Ca2+ channel activity
  • potential role in cellular signal transduction, inflammation, growth and differentiation
  • functioning as an inhibitor of coagulation owing to its ability to bind to anionic phospholipids exposed on the surface of platelets, thereby inhibiting aggregation
  • through an inducible association with IFNGR2, modulates cellular responses to IFN-gamma by modulating signaling through the Jak-Stat1 pathway
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS exocytosis transport , endocytosis transport
    text anticoagulation activity
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of chondrocytes anchorin CII collagen receptor
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Ca2+
  • phospholipid
  • protein ATRX
    cell & other
    REGULATION
    inhibited by downregulated in adult articular cartilage
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    could be responsible for immunological and hemostatic phenomena that, together, lead to fetal loss
    Susceptibility to recurrent pregnancy loss
    Variant & Polymorphism M2 promoter haplotype is a risk factor for recurrent pregnancy loss in German females
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS