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FLASH GENE
Symbol UBE2W contributors: mct - updated : 20-08-2012
HGNC name ubiquitin-conjugating enzyme E2W
HGNC id 25616
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • could regulate FANCD2 monoubiquitination by mechanisms different from UBE2T or HHR6
  • may provide an additional regulatory step in the activation of the FA pathway
  • UBE2W and ATXN3, participate in initiating, regulating, and terminating the STUB1 ubiquitination cycle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to FANCL, and the PHD domain is both necessary and sufficient for this interaction in mammalian cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS