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FLASH GENE
Symbol IFITM5 contributors: mct - updated : 17-03-2012
HGNC name interferon induced transmembrane protein 5
HGNC id
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two transmembrane domains
  • extracellular N-terminal and C-terminal sequences
  • secondary structure two helical transmembrane domains connected by an intracellular linker
    HOMOLOGY
    Homologene
    FAMILY IFITM family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • osteoblast protein, having a role in mineralization, possibly identifying a new regulatory pathway in bone formation
  • osteoblast-specific membrane protein whose expression peaks around the early mineralization stage during the osteoblast maturation process
  • is involved not only in bone formation, but also in immune system activity
  • its involvement in bone formation is widespread in mammals
  • its expression regulates the association of CD9 with the FKBP11CD81FPRP complex, and facilitates increased expression of interferon-induced genes
  • potentially contributes not only to bone formation, but also to immune system activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component IFITM5 forms a complex with FKBP11-CD81-PTGFRN
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FKBP11 is the only protein it was found to interact with in osteoblasts, while IFITM5 interacts with several proteins in fibroblasts
  • directly associates with FK506 binding protein 11 (FKBP11) in osteoblasts (FKBP11 was associated with CD81, which interacts with prostaglandin F2 receptor negative regulator (FPRP) and CD9)
  • associates with CD81 through FKBP11
  • negatively regulates the association of CD9 with a FKBP11CD81PTGFRN complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OI5
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice with a functional null mutation in the Ifitm5 gene have smaller bones