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FLASH GENE
Symbol MIR96 contributors: mct - updated : 21-09-2011
HGNC name microRNA 96
HGNC id 31648
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
  • targeting of FOXO1 by MIR96 may contribute to transformation or maintenance of an oncogenic state in breast cancer cells
  • directly targets the KRAS oncogene and functions as a tumor-suppressing miRNA in pancreatic cancer cells
  • potent regulator of KRAS
  • MIR96 downregulated FOXO3 expression by directly targeting the FOXO3a 3prime-untranslated region
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNA50
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    markedly upregulated in breast cancer cells and breast cancer tissues compared with normal breast epithelial cells (NBEC) and normal breast tissues (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS