Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TBC1D10B contributors: mct - updated : 22-12-2021
HGNC name TBC1 domain family, member 10B
HGNC id 24510
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a central TRE2 /yeast Bub2/CDC16 (TBC) domain
  • a C-terminal DAYF motif
  • HOMOLOGY
    Homologene
    FAMILY TBC1D10 subfamily
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • functions as a GAP for several proteins of the Rab family
  • TBC1D10A, TBC1D10B, TBC1D10C regulate exosome secretion in a catalytic activity-dependent manner
  • TBC1D10A, TBC1D10B, TBC1D10C subfamily members are modulators of angiogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TBC1D10B can serve as a potential physiological GAP for RAB27B and thereby participate in the regulation of exocytosis in pancreatic acinar cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS