basic FUNCTION
| nuclear nucleoside diphosphatase proteins localized within foci in the nucleolus and nucleoplasm |
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may be the nuclear counterparts of the cytoplasmic decapping machinery, localized in specialized bodies involved in RNA decay |
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plays a pivotal role in U8 snoRNA stability |
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with ITPA play a dual protective role for eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals (MID: 20081199) |
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hydrolyzes purine nucleoside diphosphates to the corresponding nucleoside monophosphates |
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may function mainly in the nucleus to protect cells from deleterious effects of (d)ITP |
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has an essential role in the maintenance of genome stability |
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like DCP2, also regulates the stability of a subset of mRNAs including a member of the motin family of proteins involved in angiogenesis, Angiomotin-like 2 (AMOTL2) |
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having pleiotropic decapping activity |
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six Nudix proteins as well as both DCP2 and NUDT16 could hydrolyze the cap of an unmethylated capped RNA, indicating that decapping enzymes may be less constrained for the presence of the methyl moiety |
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multiple Nudix family hydrolases may function in mRNA decapping and mRNA stability |
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mRNA decapping enzyme, with a role as an "housecleaning" enzyme specialized in the removal of hazardous (deoxy)inosine diphosphate from the nucleotide pool |
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