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FLASH GENE
Symbol C11orf95 contributors: mct - updated : 05-11-2010
HGNC name chromosome 11 open reading frame 95
HGNC id
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four polyglutamic rich and one proline rich region
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    t(11;16)(q13;p13), in C11orf95-MKL2 fusion oncogene in chondroid lipoma
    tumoral fusion      
    C11orf95-RELA fusions drive oncogenic NFKB signalling in ependymoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    C11orf95-RELA fusion protein is a potential therapeutic target in supratentorial ependymoma
    ANIMAL & CELL MODELS