Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SRD5A3 contributors: mct - updated : 03-11-2010
HGNC name steroid 5 alpha-reductase 3
HGNC id 25812
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to Yeast DFG10/YIL049W Gene
Homologene
FAMILY
  • steroid 5-alpha reductase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • polyprenol reductase, that is required for converting polyprenol to dolichol, confirming that the reduction of polyprenol is the major pathway for dolichol biosynthesis
  • likely to be the long-sought polyprenol reductase
  • polyprenol reductase with a crucial role in N-linked protein glycosylation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1Q , MRCCK
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hormone-refractory prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • maintenance of androgen-androgen receptor-pathway activation should be a promising molecular target for prostate cancer therapy
    • ANIMAL & CELL MODELS