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FLASH GENE
Symbol UBXN1 contributors: mct - updated : 20-10-2010
HGNC name UBX domain protein 1
HGNC id 18402
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three major domains: a UBA domain, a ubiquitin-associated motif, which recognizes autoubiquitinated BRCA1
  • a coiled-coil region
  • a UBX domain
  • C-terminal sequences bind the BRCA1/BARD1 heterodimer in a ubiquitin-independent fashion
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in ubiquitin-proteasome functions
  • regulates the enzymatic function of BRCA1 in a manner that is dependent on its ubiquitination status
  • markedly inhibits the E3 ligase activity of BRCA1/BARD1 and UBXN1 suppression of BRCA1/BARD1 enzymatic functions is dependent on the ubiquitination state of BRCA1
  • inhibits the E3 ligase activity of BRCA1/BARD1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimeric BRCA1/BARD1 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically interacted and colocalized with HOMER2 proteins, but not with HOMER1 proteins (this specific interaction may play a role in regulation of protein degradation by ubiquitin-proteasome systems, function that may be specific to HOMER2 among HOMER family proteins)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS