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FLASH GENE
Symbol WTIP contributors: mct - updated : 27-08-2015
HGNC name Wilms tumor 1 interacting protein
HGNC id 20964
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a proline-rich, pre-LIM region with a nuclear export signal
  • three C-terminal LIM protein-protein interaction domains
  • HOMOLOGY
    Homologene
    FAMILY
  • Ajuba LIM proteins family
  • zyxin/ajuba family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,nucleus
    text
  • shuttles into the nucleus after podocyte injury, providing a mechanism whereby changes in slit diaphragm structure modulate gene expression
  • basic FUNCTION
  • transcriptional corepressor for WT1, that shuttles into the nucleus after podocyte injury, translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype
  • involved in kidney and neural crest development
  • able to inhibit canonical Wnt signalling in mammalian cells
  • adaptor protein that exhibit the potential to communicate cell adhesive events with nuclear responses to remodel epithelia
  • having role as negative regulatorof the Hippo signaling pathway
  • required for microRNA-mediated gene silencing
  • coordinates cell adhesion changes and transcriptional responses to regulate podocyte phenotypic plasticity
  • ASXL2 and WTIP are involved in regulation of retinoic acid signaling during heart development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • intracellular interaction partner of ROR2
  • directly interacted with Rho guanine nucleotide exchange factor (GEF) 12 (ARHGEF12), a RhoA-specific GEF enriched in the glomerulus
  • dendrin binds to WTIP and GADD45A (WTIP and GADD45A mediate gene transcription in the nucleus, suggesting that dendrin may have similar functions in podocytes
  • is a ASXL2-binding partner
  • NCK1 integrates NPHS1 with the Hippo kinase cascade through association with the adaptor protein WTIP
  • WTIP interacts with BRCA2 and might be responsible for BRCA2 centrosome localization in cervical cancer cell
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    UBA2-WTIP is an oncogenic fusion gene, in acute myeloid leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    UBA2-WTIP fusion is a promising therapeutic target for the treatment of acute myeloid leukemia
    ANIMAL & CELL MODELS