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FLASH GENE

Symbol

IL6R

contributors: mct - updated : 13-09-2017

HGNC name	interleukin 6 receptor
HGNC id	6019

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

CATEGORY

signaling cytokine , receptor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,nucleus

basic FUNCTION

involved in the regulation of the immune response, acute-phase reactions and hematopoiesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	heterodimerizing with IL6ST
	hexamer of two molecules each of IL6, IL6R and IL6ST

INTERACTION

DNA

RNA

small molecule

protein

TRAF5 is a negative regulator of the IL6R signaling pathway that limits the induction of proinflammatory CD4(+) T cells that require IL6 for their development

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS