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FLASH GENE
Symbol IL6R contributors: mct - updated : 13-09-2017
HGNC name interleukin 6 receptor
HGNC id 6019
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
Homologene
FAMILY
CATEGORY signaling cytokine , receptor
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
    intracellular
intracellular,nucleus
basic FUNCTION involved in the regulation of the immune response, acute-phase reactions and hematopoiesis
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
  • heterodimerizing with IL6ST
  • hexamer of two molecules each of IL6, IL6R and IL6ST
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRAF5 is a negative regulator of the IL6R signaling pathway that limits the induction of proinflammatory CD4(+) T cells that require IL6 for their development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS