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FLASH GENE
Symbol ULK3 contributors: mct - updated : 16-02-2011
HGNC name unc-51-like kinase 3 (C. elegans)
HGNC id 19703
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two MIT domains
  • one protein kinase domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Ulk3 (94.1pc)
    homolog to rattus Ulk3 (94.6pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • APG1/unc-51/ULK1 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • protein serine/threonine kinase activity
  • able to regulate GLI proteins positively in a kinase activity-dependent manner
  • involved in the SHH pathway as a positive regulator of GLI proteins
  • phosphorylation of GLI1 by ULK3 results in GLI1 nuclear accumaltion
  • participates in the transduction of the SHH signal also independently of its kinase activity
  • a potential dual function in the SHH signal transduction pathway and an additional way of regulating GLI proteins by SUFU, through binding to and suppression of ULK3
  • able to enhance the activity of GLI1 and GLI2 proteins in a kinase activity-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
  • through its kinase domain interacts with Suppressor of Fused (SUFU), a protein required for negative regulation of Gli proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    induces autophagy and senescence
    Susceptibility
    Variant & Polymorphism SNP SNp is associated with blood pressure and/or hypertension in the Japanese
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS