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FLASH GENE
Symbol ODAM contributors: mct - updated : 21-01-2021
HGNC name odontogenic ameloblast-associated
HGNC id 26043
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • ODAM family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,cytoplasm,cytoskeleton,microfilament
    intracellular,nucleus,nucleoplasm
    text
  • during the secretory stage of amelogenesis ODAM was localized to both the nucleus and cytoplasm of ameloblasts
  • basic FUNCTION
  • may predicts survival in breast cancer
  • likely involved in dental development
  • developmental antigen that has an essential role in tooth maturation and in the pathogenesis of certain odontogenic and other epithelial neoplasms
  • presence at cell-tooth interfaces suggests involvement in adhesive mechanisms active at epithelial cells of the gingiva which bind it to the tooth surface, but its presence among other epithelial tissues indicates ODAM likely possesses broader physiological roles
  • plays important roles in enamel mineralization through the regulation of matrix metalloproteinase-20 (MMP20)
  • present in multiple cellular compartments of differentiating odontogenic and cancer cell lines with important functional implications
  • AMTN and ODAM, participates in structuring the basal lamina and in mediating attachment of epithelia cells to mineralised tooth surfaces
  • critical role for ODAM in inducing cancer cell adhesion
  • ODAM expression maintains their adhesion, resulting in the prevention of their metastasis via the regulation of RhoA signalling in breast cancer cells
  • ODAM expression in the Dental follicle (DF) may regulate bone formation for timely tooth eruption
  • AMTN, and ODAM participate in structuring an extracellular matrix with the distinctive capacity of attaching epithelial cells to mineralized surfaces
  • ODAM promotes junctional epithelium-related gene expression via the ODAM-WNT1 axis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with RUNX2 (RUNX2 regulates the expression of ODAM and nuclear ODAM serves an important regulatory function in the mineralization of enamel through the regulation of MMP20 apart from a different, currently unidentified, function of extracellular ODAM)
  • ODAM and BMPRIB interacted through the C-terminus of ODAM, which resulted in increased ODAM phosphorylation in the presence of BMP2
  • distinct expression of AMTN and ODAM and their interaction are likely involved in defining the enamel microstructure at the enamel surface
  • functional correlations exist between ODAM and MMP20
  • DLX3 promotes the expression of the enamel matrix protein (EMP) genes AMELX, ENAM, KLK4, and ODAM in amelogenesis, while mutant-DLX3 disrupts this regulatory function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    ODAM expression level was closely correlated with Colorectal cancer development and patient prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • novel biomarker for human breast cancer
  • could be used as a biomarker of periodontitis and peri-implantitis
  • matricellular protein ODAM may serve as a novel prognostic marker in Colorectal cancer
  • Marker
    Therapy target
  • may serve as a novel prognostic biomarker, as well as a potential diagnostic and therapeutic target for patients with breast and other epithelial forms of cancer
  • ANIMAL & CELL MODELS
  • Odam KO mice showed destruction of the integrity of the junctional epithelium, which detaches from teeth