SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,cytoplasm,cytoskeleton,microfilament
|
| intracellular,nucleus,nucleoplasm
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text
| during the secretory stage of amelogenesis ODAM was localized to both the nucleus and cytoplasm of ameloblasts |
basic FUNCTION
| may predicts survival in breast cancer |
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likely involved in dental development |
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developmental antigen that has an essential role in tooth maturation and in the pathogenesis of certain odontogenic and other epithelial neoplasms |
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presence at cell-tooth interfaces suggests involvement in adhesive mechanisms active at epithelial cells of the gingiva which bind it to the tooth surface, but its presence among other epithelial tissues indicates ODAM likely possesses broader physiological roles |
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plays important roles in enamel mineralization through the regulation of matrix metalloproteinase-20 (MMP20) |
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present in multiple cellular compartments of differentiating odontogenic and cancer cell lines with important functional implications |
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AMTN and ODAM, participates in structuring the basal lamina and in mediating attachment of epithelia cells to mineralised tooth surfaces |
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critical role for ODAM in inducing cancer cell adhesion |
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ODAM expression maintains their adhesion, resulting in the prevention of their metastasis via the regulation of RhoA signalling in breast cancer cells |
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ODAM expression in the Dental follicle (DF) may regulate bone formation for timely tooth eruption |
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AMTN, and ODAM participate in structuring an extracellular matrix with the distinctive capacity of attaching epithelial cells to mineralized surfaces |
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ODAM promotes junctional epithelium-related gene expression via the ODAM-WNT1 axis |