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FLASH GENE
Symbol MZT1 contributors: mct - updated : 16-12-2016
HGNC name mitotic spindle organizing protein 1
HGNC id 33830
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast Mzt1
Homologene
FAMILY
  • UPF0582 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    basic FUNCTION
  • MZT1, MZT2A, MZT2B copurified with subunits of the gamma-tubulin ring complex (gamma-TuRC), which is essential for spindle assembly and chromosome segregation
  • plays a unique role within the TUBG1 components in attachment of this complex to the major microtubule organizing centers (MTOCs) site
  • plays an essential role in mitotic spindle formation as a component of the Gamma-tubulin ring complex
  • MST1 contributes to the microtubule-organizing centers (MTOCs) function through regulation of TUBGCP3
  • MZT1 is a 'priming factor' for gamma-tubulin ring complex (GTuRC) that allows spatial regulation of nucleation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • a direct interaction between recombinant MST1 and the N-terminal region of TUBGCP3
  • recognition of gamma-tubulin ring complex integrity is mediated by MZT1, which binds not only to the TUBGCP3 subunit as previously shown, but cooperatively also to other GCPs through a conserved hydrophobic motif present in the N-termini of TUBGCP2, TUBGCP3, TUBGCP5 and TUBGCP6
  • MZT1 specifically binds fully assembled GTuRC to enable interaction with NEDD1 for targeting, and with the CM1 domain of CDK5RAP2 for stimulating nucleation activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS