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FLASH GENE
Symbol PATL1 contributors: mct - updated : 11-05-2010
HGNC name protein associated with topoisomerase II homolog 1 (yeast)
HGNC id 26721
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • very N-terminal A region which mediates binding to DDX6, (this domain has an astonishing number of 32 acidic AAs within its 84 AAs and it will be interesting to determine whether the PATL1 A domain has an influence on the nucleotide binding or helicase activity of DDX6)
  • the acidic domain (A) at the very N-terminus (AA 1 to 84) influences the size of P bodies
  • HOMOLOGY
    Homologene
    FAMILY
  • PAT1 family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • accumulate in processing bodies (P bodies) together with other proteins of the 5'-3'-deadenylation-dependent mRNA decay pathway
  • strongly accumulates in small cytoplasmic foci
  • basic FUNCTION
  • having functions in the opposing processes of mRNA translation and mRNA degradation, thus suggesting an important regulatory role
  • its expression was required for P body formation
  • physically and functionally connects the deadenylation and decapping machinery, and also controls the assembly of P bodies
  • appears to have a scaffold function since it interacts with its partners through at least three different domains
  • when targeted to a reporter mRNA, represses gene expression by inducing deadenylation of the mRNAs
  • acts as an mRNA-specific deadenylation factor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • is clearly a central component of the RNA decay machinery
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with all enhancers of decapping through at least three separate domains: the A fragment associates with DDX6, the N fragment with DCP2 and DCP1A, and the HC fragment with DCP2/DCP1a, LSM1/LSM4, EDC4, and EDC3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS