basic FUNCTION
| histone methyltransferases activity (Schotta 2004) |
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may be recruited to heterochromatin in association with CBX1, CBX3, CBX5, and stably maintained at its heterochromatin sites in an CBX-independent fashion (Souza 2009) |
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KMT5B, KMT5C differ substantially in their localization and activity |
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can induce a transition from H4K20me1 to H4K20me3 in regions of constitutive heterochromatin that is sufficient to enhance myogenic differentiation, suggesting it can act an as epigenetic 'switch' in this process |
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KMT5B, KMT5C are two highly homologous enzymes that methylate lysine 20 of histone H4 (H4K20), a mark that has been implicated in transcriptional regulation |
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is required for matrix mineralization during osteoblast differentiation, and controls the H4K20 methylome of osteoblasts and is critical for normal progression of osteoblastogenesis |