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FLASH GENE
Symbol CDKN2B-AS1 contributors: mct/npt/pgu - updated : 27-11-2014
HGNC name CDKN2B antisense RNA (non-protein coding)
HGNC id 34341
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION
basic FUNCTION modulation of ANRIL expression mediates susceptibility to a range of important human diseases
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
  • expression levels of CDKN2A, CDKN2B, and CDKN2BAS are positively correlated
  • within the polycomb repressive complex 1 binds to CDKN2BAS and both CBX7 and CDKN2BAS are found at elevated levels in prostate cancer tissues
  • cell & other
    REGULATION
    Other its effects may be mediated through antisense transcription regulation of CDKN2B in the tissues critical for the pathogenesis of the different diseases
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to risk for aggressive periodontitis
  • to coronary artery disease (CAD) and periodontitis
  • Variant & Polymorphism other
  • specific variants associated with highly increased risk for aggressive periodontitis (AgP)
  • risk alleles in the genes CDKN2B-AS1, CAMTA1 and PLG that are shared between coronary artery disease (CAD) and periodontitis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS