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FLASH GENE
Symbol SLC47A1 contributors: mct/npt/pgu - updated : 07-10-2015
HGNC name solute carrier family 47, member 1
HGNC id 25588
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular C terminus with 13, not 12, transmembrane helices, but the 13th TMH is not necessary for transport function, but it may influence turnover activity of the transporter
  • HOMOLOGY
    Homologene
    FAMILY
  • multidrug and toxic compound extrusion (MATE) proteins family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • highly expressed in peroxisomes and the endoplasmic reticulum (ER) as well as in plasma membranes
  • expressed at the brush-border membranes
  • basic FUNCTION
  • mediates H(+)-coupled electroneutral exchange of tetraethylammonium and 1-methyl-4-phenylpyridinium
  • function together as a detoxication system, by mediating the tubular secretion of intracellular ionic compounds across the brush-border membranes of the kidney
  • play important roles in the renal tubular secretion of cationic drugs
  • able to transport tetraethylammonium (TEA) utilizing an oppositely directed H+ gradient as a driving force
  • play crucial roles in the renal handling of cationic drugs, such as cimetidine, metformin and oxaliplatin
  • SLC47A1 and SLC22A2 are transport systems that may be of importance for the cellular disposition of agmatine and putrescin
  • mediates renal organic cation secretion
  • SLC47A1, SLC47A2, are critical players in the luminal export of organic cations (OCs) from renal proximal tubule cells in human kidney
  • mediates drug secretion into urine at the brush-border membranes
  • H(+)-coupled organic cation exporter responsible for the final step of excretion of various xenobiotics at the kidney and liver
  • membrane transporter for flavonoids and has a high affinity for quercetin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coordinate function of SLC47A1 with SLC22A2 likely contributes to the vectorial renal elimination of organic cationic drugs
  • DDAH1 and L-arginine are substrates of human SLC7A2, SLC22A2, SLC47A1
  • is a membrane transporter for quercetin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    of SLC22A3 and SLC47A1 in human placenta indicates these transporters may play a role in fetal protection preferentially at earlier stages of gestation
    constitutional       loss of function
    caused a marked elevation in the metformin concentration in the liver and led to lactic acidosis
    Susceptibility to drug-induced nephrotoxicity
    Variant & Polymorphism SNP
  • significant decrease in transport activity, and especially G64D were completely abolished by the impairment of cell surface expression leading to drug-induced nephrotoxicity
  • nonsynonymous variants in hMATE1 may alter drug disposition and ultimately affect clinical drug response
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS