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FLASH GENE
Symbol NUP107 contributors: mct - updated : 14-11-2017
HGNC name nucleoporin 107kDa
HGNC id 29914
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Nup107 (91.5pc)
homolog to rattus Nup107 (91.8pc)
Homologene
FAMILY
  • nucleoporin Nup84/Nup107 family
  • CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,chromatin/chromosome,kinetochore
    intracellular,nuclear envelope,pore
    text
  • cytoplasmic and nuclear sides of the nuclear pores
  • localized to the kinetochores during mitosis (Loiodice 2004)
  • remain incorporated in the nuclear membrane during the entire cellular life span (D'Angelo 2009)
  • within the nucleoplasm, a fraction of NUP107, a key component of the Y-complex, displays reduced mobility, suggesting interaction with other nuclear component
  • distributed in a speckle-like pattern in the nuclei of human podocytes surrounding the glomerular capillary tufts
  • basic FUNCTION
  • required for the assembly of peripheral proteins into the nuclear pore complex
  • involved in RNA export and in tethering NUP98 and NUP153 to the nucleus
  • involved in proper kinetochore functions (Zuccolo 2007)
  • facilitates the efficient transfer of macromolecules between the nucleus and cytoplasm in a highly selective manner and plays pivotal roles in the nuclear framework and gene expression
  • with NUP133, form elongated structures that interact tightly via a compact interface in tail-to-tail fashion
  • key scaffold protein in nuclear pore complex assembly
  • may contribute significantly to the regulation of cell fate in aged and transformed cells by modulating nuclear trafficking of signal molecules
  • critical regulator of the DNA damage-induced intra-S phase checkpoint response, involved in DNA damage-induced nuclear translocation of APAF1
  • likely has an important function for renal filtration in human podocytes
  • pivotal role for NUP107 in ovarian development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the Nup160 subcomplex which is composed of NUP160, NUP133, NUP107 and NUP96
  • age-related deterioration of the complex is involved in increase in nuclear permeability and the leaking of cytoplasmic proteins into the nucleus (D'Angelo 2009)
  • NUP107-160 complex interacts with CENPF, but CENPF only moderately contributes to its targeting to kinetochores
  • KPNB1 forms a high-molecular-weight complex with both AHCTF1 and the NUP107-160 complex in cytosol
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NUP107-160 interacts with the gamma-tubulin ring complex (gamma-TuRC), an essential and conserved microtubule nucleator, and recruits gamma-TuRC to unattached kinetochores
  • unexpected connection with the mitotic spindle assembly checkpoint protein MAD1L1
  • APAF1 associates with the nucleoporin NUP107 and this association is necessary for APAF1 nuclear import
  • NUP107 interacts with NUP133 via its C-terminal tail
  • cell & other
    REGULATION
    Other phosphorylated upon DNA damage probably by ATM or ATR (Glavy 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s) SRN6 , XXGD2 , GAMOS7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in Drosophila, Nup107 knockdown in somatic gonadal cells resulted in female sterility, whereas males were fully fertile