SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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| intracellular,nuclear envelope,pore
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text
| cytoplasmic and nuclear sides of the nuclear pores |
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localized to the kinetochores during mitosis (Loiodice 2004) |
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remain incorporated in the nuclear membrane during the entire cellular life span (D'Angelo 2009) |
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within the nucleoplasm, a fraction of NUP107, a key component of the Y-complex, displays reduced mobility, suggesting interaction with other nuclear component |
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distributed in a speckle-like pattern in the nuclei of human podocytes surrounding the glomerular capillary tufts |
basic FUNCTION
| required for the assembly of peripheral proteins into the nuclear pore complex |
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involved in RNA export and in tethering NUP98 and NUP153 to the nucleus |
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involved in proper kinetochore functions (Zuccolo 2007) |
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facilitates the efficient transfer of macromolecules between the nucleus and cytoplasm in a highly selective manner and plays pivotal roles in the nuclear framework and gene expression |
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with NUP133, form elongated structures that interact tightly via a compact interface in tail-to-tail fashion |
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key scaffold protein in nuclear pore complex assembly |
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may contribute significantly to the regulation of cell fate in aged and transformed cells by modulating nuclear trafficking of signal molecules |
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critical regulator of the DNA damage-induced intra-S phase checkpoint response, involved in DNA damage-induced nuclear translocation of APAF1 |
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likely has an important function for renal filtration in human podocytes |
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pivotal role for NUP107 in ovarian development |