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FLASH GENE
Symbol HCK contributors: mct - updated : 08-04-2015
HGNC name hemopoietic cell kinase
HGNC id 4840
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SH3 and SH2 domains, playing important roles in substrate targeting, noncatalytic regions working together as a "conformational switch" that modulates kinase activity in a manner unique to the SH3 domain and linker topologies present in the intact HCK protein
  • a bipartite kinase domain
  • HOMOLOGY
    interspecies homolog to rattus Hck (89.89 pc)
    homolog to murine Hck (90.08 pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • Src-family kinases
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • contributing to neutrophil migration and regulating the degranulation process of neutrophils
  • EIF2AK2 and HCK were critical for DON-induced ribosomal recruitment of MAPK14, its subsequent phosphorylation, and, ultimately, MAPK14-driven proinflammatory cytokine expression
  • acts as a key regulator controlling gene expression in alternatively activated monocytes/macrophages
  • major signaling kinase in alternatively activated monocytes/macrophages by IL13, implicating a central role for SRC family kinases in atherogenesis and chronic inflammation
  • critical for regulating alternative activation of monocytes/macrophages
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with ADAM15 (regulates leukocyte function)
  • interacting with RAPGEF1, to activate kinase-dependent and caspase-mediated apoptosis, which is independent of catalytic domain of C3G
  • recruited by integrin alpha(M)beta(2)
  • interacting with TP73 (HCK-SH3 domain-mediated interactions play an important role in the inhibition of TP73-dependent transcriptional activation of a target gene, NLRC4, as well as apoptosis)
  • interacting with CSF1R (dysregulated activation of HCK at the Golgi disturbs N-glycosylation of a cytokine receptor CSF1R)
  • PDCD6IP is a novel HCK (haemopoietic cell kinase) SH3 domain interactor
  • regulates the expression of mannose receptor, CD36, and MAOA in alternatively activated monocytes by IL13
  • C-terminal 40 amino acids of HCK selectively bound to NLRP12 PYD + NBD
  • cell & other
  • membrane associated
  • REGULATION
    activated by Gproteins alphaS and alphaI
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS