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FLASH GENE
Symbol LRRC26 contributors: mct - updated : 25-06-2014
HGNC name leucine rich repeat containing 26
HGNC id 31409
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a classical N-terminal cleavable signal peptide for extracellular localization of its large N-terminal LRR domain (five 24-AA LRR motifs with a consensus sequence LXXLXLXXN)
  • a single transmembrane domain
  • a short intracellular C terminus
  • HOMOLOGY
    intraspecies paralog to LRRC55, LRRC38, LRRC52
    Homologene
    FAMILY
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton
    text type I single-span membrane protein
    basic FUNCTION
  • modulates the gating of KCNMA1 by enhancing the allosteric coupling between voltage-sensor activation and the channel closed–open transition
  • role in the suppression of tumor growth and metastasis may be through its alteration of the tumor microenvironment
  • LRRC52 and LRRC26 define a new family of auxiliary subunits capable of critically modifying the gating behavior of Slo family channels
  • LRRC52, LRRC55, and LRRC38 potentially function as LRRC26-type auxiliary subunits of BK channels
  • LRRC26 and its paralogs are structurally and functionally distinct from the beta-subunits and are a gamma family of the BK channel auxiliary proteins, which potentially regulate the channel gating properties over a spectrum of different tissues or cell types
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • belongs to an extracellular leucine-rich-repeat–only (Elron) cluster, which includes five other LRRC proteins: LRRC38, LRRC52, LRRC55, LRTM1 and LRTM2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • auxiliary protein of BK channels that can associate with KCNMA1
  • both LRRC26 and LRRC52 are able to modify KCNU1 function
  • associates with KCNMA1 subunits, and elevates channel voltage- and apparent Ca2+-sensitivity in arterial myocytes to induce vasodilation (PMID;
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate, breast, colon and pancreas cancer tissues or cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS