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FLASH GENE
Symbol CCDC88B contributors: mct - updated : 05-02-2009
HGNC name coiled-coil domain containing 88B
HGNC id 26757
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminus containing a putative microtubule-binding domain that can bind microtubules in the Hook protein
  • the central region of each protein is comprised of an extensive coiled-coil domain
  • several conserved domains, including a unique C-terminal HkRP domain (Simpson 2005)
  • HOMOLOGY
    Homologene
    FAMILY
  • Hook-related protein (HkRP) family, CCDC88 family
  • Girdin family protein
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be functioning in linking organelles to microtubules*
  • having a protective role in endoplasmic reticulum stress responses in endothelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component CCDC88B/GRP78 interaction controls the IRE1-JNK signaling pathway to protect endothelial cells against ER stress-induced apoptosis in pathological contexts such as atherosclerosis and vascular endothelial dysfunction
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in endothelial cells, interacts with GRP78, a master regulator of the unfolded protein response
  • stabilizes the interaction between GRP78 and the ER stress sensor inositol-requiring protein 1 (IRE1) at the ER, leading to the attenuation of IRE1-induced c-Jun N-terminal kinase (JNK) activation
  • cell & other
    REGULATION
    induced by upon ER stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS