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FLASH GENE
Symbol GABRA2 contributors: mct - updated : 22-09-2020
HGNC name gamma-aminobutyric acid (GABA) A receptor, alpha 2
HGNC id 4076
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a ligand binding site in the N terminal region,
  • four transmembrane segments (4TM),one of which forming the wall of the channel and
  • a large intracellular loop
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • NPTN specifically co-localizes with GABRA1 and GABRA2 but not with GABRA3 subunits at GABAergic synapses
    • basic FUNCTION major inhibitory neurotransmitter in the vertebrate brain, mediating neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of a pentameric receptor mediating inhibitory neurotransmission
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ovarian cycle-related Progesterone and neurosteroids regulate GABRA2 expression in the hippocampus via a non-PGR pathway, which may be relevant to menstrual-cycle related brain conditions
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE78
    Susceptibility
  • susceptibility to alcohol dependence by modulating the level of neural excitation
    • Variant & Polymorphism other genetic variations in GABRA2 might play a role in the risk of alcohol use disorders by moderating the subjective effects of alcohol
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatry  
    may therefore represent a novel target for the development of more effective antidepressants
    ANIMAL & CELL MODELS
  • genetic inactivation of Gabra2 would generate a depressive-like phenotype in mice