SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton
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| intracellular,nucleus,nucleoplasm
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text
| earlier reported to localize in the cytoplasm and interact with and phosphorylate cytoskeletal structures, but its presence in the TCF4 transcriptional complex suggested nuclear localization (Mahmoudi 2009) |
basic FUNCTION
| a member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton (Fu 1999) |
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inducing disruption of F-actin structure, thereby inhibiting cell spreading, specific effector of RAP2A to regulate actin cytoskeleton (Taira 2004) |
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specific effector of Rap2 proteins (Uechi 2009) |
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is essential for the activation of both the canonical Wnt pathway and the JNK pathway, and serves as a pro-survival factor. |
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is a novel key player in TRAF6-dependent JNK and NF-& |
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954;B signaling and a transducer of activating and transforming signals in human B-cells. |
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as a critical regulator of cognitive functions and suggest it may play a regulatory role in diseases impacting on its interacting proteins and complexes |
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dynamic change of TNIK offers a way to protect cells from outside stimulus |
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involved in cytoskeleton organization and neuronal dendrite extension |
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is essential for activation of WNT signaling pathway in colon cancer growth |
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is highly enriched at a microdomain critical for glutamatergic signaling |
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might play a crucial role in pancreatic carcinogenesis |
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is required for the tumour-initiating function of colorectal cancer stem cells |